DepoDur: Overview

Extended Postoperative
Pain Relief After
Major Surgery

Superior pain relief for up to 48 hours 
with a single epidural injection of extended-
release morphine, compared to IV PCA1, 2,*
or conventional epidural MS injection3-5

Efficacy shown by multiple measures 
in patients undergoing various
surgical procedures1-5


No Indwelling
Epidural Catheter

Postoperative anticoagulation
of appropriate patients 
that avoids the limitations of indwelling catheter use6,7

Premits VTE* prophylaxis without delay

Avoidance of complications and restrictions
related to epidural catheters 

Infection8-11
Epidural hematoma8,9,12
Catheter kinking, dislodgement, migration8,9,12
Impaired patient mobility12

 

DepoDur is contraindicated in patients with known hypersensitivity to morphine or the product components and those patients with respiratory depression, acute or severe bronchial asthma, upper airway obstruction; those who have or are suspected of having paralytic ileus, head injury, or increased intracranial pressure; and those who are in circulatory shock. Any contraindications for an epidural injection preclude use of DepoDur.

*Intravenous patient-controlled analgesia.
† Morphine sulfate.
‡ Venous thromboembolism.

 

Important Safety Information

DepoDur is not intended for intrathecal, intravenous, or intramuscular administration. Administration of DepoDur into the thoracic epidural space or higher has not been evaluated and therefore is not recommended. The majority of adverse events were typical opioid-related side effects and would be expected in the surgical populations studied. No statistically significant differences between treatment groups with respect to nausea, pruritus, sedation scores, vomiting episodes, or urinary retention.   

More information on safety page.

Please see full Prescribing Information.

 

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